HYDROXYALKYLPHOSPHINES IN ASYMMETRIC HYDROGENATIONS

被引：39

作者：

HOLZ, J ^{[1
]}

BORNER, A ^{[1
]}

KLESS, A ^{[1
]}

BORNS, S ^{[1
]}

TRINKHAUS, S ^{[1
]}

SELKE, R ^{[1
]}

HELLER, D ^{[1
]}

机构：

[1] UNIV ROSTOCK,MAX PLANCK GESELL,ASYMMETR KATALYSE ARBEITSGRP,D-18055 ROSTOCK,GERMANY

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 08期

关键词：

D O I：

10.1016/0957-4166(95)00257-P

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The synthesis of chiral bisphosphines bearing a hydroxyl group in a rigid backbone is described. These compounds which are analogues of the prominent ligand DIOP formed definite rhodium complexes. IR spectra provided evidence that the hydroxyl groups do not participate in the complexation to the metal or to one of the acetal oxygen atoms. The complexes have proven successful in the asymmetric hydrogenation of prochiraI functionalized olefins in different solvents. In methanol only small effects could be detected in comparison to parent complexes which do not carry a hydroxyl group. However, when hydrogenations were performed in methylene chloride Or toluene significant differences in the enantioselectivities (by up to 17%ee) were observed, especially in the reaction with itaconic acid or its dimethyl ester, respectively. In the latter cases the effect is contingent on the spatial orientation of the hydroxyl group in the catalyst.

引用

页码：1973 / 1988

页数：16

共 48 条

[1]

Kagan, Chiral Ligands for Asymmetric Catalysis, Asymmetric Synthesis, 5, (1985)

[2]

Brunner, Topics in Stereochemistry, 18, (1988)

[3]

Blystone, Chem. Rev., 89, (1989)

[4]

Ojima, Clos, Bastos, Tetrahedron, 45, (1989)

[5]

Noyori, Asymmetric Catalysis in Organic Synthesis, (1994)

[6]

Chaloner, Esteruelas, Joo, Oro, Homogeneous Hydrogenation, (1994)

[7]

Koenig, The Applicability of Asymmetric Homogeneous Catalytic Hydrogenation, Asymmetric Synthesis, 5, (1985)

[8]

Brunner, Zettlmeier, Handbook of Enantioselective Catalysis with Transition Metal Compounds, 1-2, (1993)

[9]

Ward, Borner, Kagan, Tetrahedron: Asymmetry, 3, (1992)

[10]

Hayashi, Asymmetric Catalysis with Chiral Ferrocenylphosphine Ligands, Ferrocens, (1995)

← 1 2 3 4 5 →