LITHIUM TREATMENT RESTORES CLONIDINES EFFECT IN AN ANIMAL-MODEL OF DEPRESSION

被引：4

作者：

AULAKH, CS

HILL, JL

MURPHY, DL

机构：

[1] Laboratory of Clinical Science, National Institute of Mental Health, Bethesda

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1994年 / 47卷 / 04期

关键词：

ALPHA(2)-ADRENERGIC HETERORECEPTORS; 5-HT1C RECEPTORS; DEPRESSION; GROWTH HORMONE; FAWN-HOODED RAT;

D O I：

10.1016/0091-3057(94)90308-5

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

IP administration of various doses of clonidine produces significant increases in growth hormone levels in the Wistar rats but not in the Fawn-Hooded (FH) rats, a rat strain suggested to be a genetic model of depression. However, short-term lithium treatment restores clonidine's effect on growth hormone levels in the Fawn-Hooded rats. Potentiation of clonidine's effect on growth hormone levels following short-term lithium treatment appears most likely due to increased serotonergic function as a consequence of enhanced 5-HT concentrations at postsynaptic 5-HT1C receptor sites. Thus, the reversal of a deficit state in Fawn-Hooded rats by lithium treatment supports earlier studies suggesting this rat strain to represent a genetic model of depression.

引用

页码：985 / 987

页数：3

共 17 条

[1]

AULAKH C S, 1991, Journal of Psychopharmacology, V5, P149, DOI 10.1177/026988119100500209

[2] LONG-TERM LITHIUM TREATMENT IN RATS ATTENUATES M-CHLOROPHENYLPIPERAZINE-INDUCED DECREASES IN FOOD-INTAKE BUT NOT LOCOMOTOR-ACTIVITY [J].