INCREASE IN SIALIC ACIDS REMOVABLE BY NEURAMINIDASE DURING SHAPE CHANGE OF PLATELETS

被引：19

作者：

MOTAMED, M ^{[1
]}

MICHAL, F ^{[1
]}

BORN, GVR ^{[1
]}

机构：

[1] UNIV CAMBRIDGE, SCH MED, DEPT PHARMACOL, CAMBRIDGE CB2 2QD, ENGLAND

来源：

BIOCHEMICAL JOURNAL | 1976年 / 158卷 / 03期

关键词：

D O I：

10.1042/bj1580655

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human or rabbit platelets were activated by ADP or 5-hydroxytryptamine and rapidly fixed with glutaraldehyde. The shape change associated with activation gave rise to an increase in sialic acids removable by neuraminidase. This increase, like the shape change, was prevented by adenosine or methysergide added before ADP or 5-hydroxytryptamine, respectively. The results indicated the exposure of additional glycoprotein(s) on the platelet surface.

引用

页码：655 / 657

页数：3

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