THERAPEUTIC SUCCESS OF EPIDERMAL GRAFTING IN GENERALIZED VITILIGO IS LIMITED BY THE KOEBNER PHENOMENON

被引:65
作者
HATCHOME, N [1 ]
KATO, T [1 ]
TAGAMI, H [1 ]
机构
[1] TOHOKU UNIV,SCH MED,DEPT DERMATOL,1-1 SEIRYO MACHI,SENDAI,MIYAGI 980,JAPAN
关键词
D O I
10.1016/0190-9622(90)70013-8
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Eighteen patients with vitiligo (two with localized type, five with segmental type, and 11 with generalized type) were treated with an epidermal graft using the roof of a suction blister. In all patients with localized and segmental lesions and in seven with generalized lesions, successful repigmentation without scarring was observed at the grafted sites approximately 2 to 3 weeks after grafting, and a subsequent two- to threefold expansion of the pigmented area occurred within 3 to 4 months. On the other hand, no repigmentation could be achieved in four patients with generalized vitiligo in whom depigmentation (i.e., the Koebner phenomenon) occurred at the donor sites. Our results suggest that the Koebner phenomenon occurs in an all-or-none pattern only in patients with generalized vitiligo. Thus, although epidermal grafting is a simple and useful method, successful repigmentation at the recipient sites depends on the selection of patients with localized lesions in whom the Koebner phenomenon does not develop. © 1989, American Academy of Dermatology, Inc.. All rights reserved.
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页码:87 / 91
页数:5
相关论文
共 13 条
[1]  
BEHL PN, 1973, J DERMATOL, V12, P329
[2]   BRASSIERE DEPIGMENTATION - LIGHT AND ELECTRON MICROSCOPE STUDIES [J].
BLEEHEN, SS ;
HALLSMIT.P .
BRITISH JOURNAL OF DERMATOLOGY, 1970, 83 (01) :157-&
[3]   PIGMENTATION INDUCED IN VITILIGO BY NORMAL SKIN-GRAFTS AND PUVA STIMULATION - A PRELIMINARY-STUDY [J].
BONAFE, JL ;
LASSERE, J ;
CHAVOIN, JP ;
BARO, JP ;
JEUNE, R .
DERMATOLOGICA, 1983, 166 (03) :113-116
[5]   TREATMENT OF LOCALIZED VITILIGO BY AUTOLOGOUS MINIGRAFTING [J].
FALABELLA, R .
ARCHIVES OF DERMATOLOGY, 1988, 124 (11) :1649-1655
[6]   A STUDY OF LESION OF VITILIGO [J].
GOPINATHAN, T .
ARCHIVES OF DERMATOLOGY, 1965, 91 (04) :397-+
[7]  
Haxthausen H., 1947, ACTA DERM-VENEREOL, V27, P352
[9]  
KRUEGER GG, 1981, YB DERMATOLOGY 1981, P13
[10]   TRANSPLANTATION OF HUMAN MELANOCYTES [J].
LERNER, AB ;
HALABAN, R ;
KLAUS, SN ;
MOELLMANN, GE .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1987, 89 (03) :219-224