CHARACTERIZATION OF IMMUNOREACTIVE OCTAPEPTIDES OF HUMAN-CYTOMEGALOVIRUS-GP58

被引：4

作者：

BONCI, A ^{[1
]}

BRACCI, L ^{[1
]}

CAUDAI, C ^{[1
]}

LOZZI, L ^{[1
]}

MOSCHETTINI, D ^{[1
]}

NICCOLAI, N ^{[1
]}

SCARSELLI, M ^{[1
]}

VALENSIN, PE ^{[1
]}

NERI, P ^{[1
]}

机构：

[1] UNIV SIENA,DIPARTIMENTO BIOL MOLEC,PIAN MANTELLINI 44,I-53100 SIENA,ITALY

来源：

EUROPEAN JOURNAL OF BIOCHEMISTRY | 1993年 / 215卷 / 02期

关键词：

D O I：

10.1111/j.1432-1033.1993.tb18044.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have mapped continuous epitopes, for positions 591-673 of the human cytomegalovirus 58-kDa glycoprotein using overlapping synthetic peptides and human sera. This region contains a fragment previously described as including the dominant site for induction of human-cytomegalovirus antibodies. Since the selected sequence is highly conserved among herpes viruses, we have considered the possible presence of antigenic cross-reactivity, particularly with the Epstein-Barr virus. Several peptides in the studied region were antigenic and two main continuous epitopes have been identified. Serological cross-reactions observed with Epstein-Barr virus are discussed, focussing on the possible implications of structural features and sequence similarity between human-cytomegalovirus and Epstein-Barr-virus glycoproteins.

引用

页码：383 / 387

页数：5

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