ARE ACTIVATING MUTATIONS OF THE ADRENOCORTICOTROPIN RECEPTOR INVOLVED IN ADRENAL-CORTICAL NEOPLASIA

被引：53

作者：

LIGHT, K

JENKINS, PJ

WEBER, A

PERRETT, C

GROSSMAN, A

PISTORELLO, M

ASA, SL

CLAYTON, RN

CLARK, AJL

机构：

[1] ST BARTHOLOMEWS HOSP,COLL MED,DEPT CHEM ENDOCRINOL,LONDON EC1A 7BE,ENGLAND

[2] ST BARTHOLOMEWS HOSP,COLL MED,DEPT ENDOCRINOL,LONDON EC1A 7BE,ENGLAND

[3] KEELE UNIV,DEPT MED,STOKE ON TRENT ST4 7QB,STAFFS,ENGLAND

[4] UNIV PADUA,OSPED 105,DEPT MED,I-35100 PADUA,ITALY

[5] UNIV TORONTO,MT SINAI HOSP,DEPT PATHOL,TORONTO,ON M5G 1X5,CANADA

来源：

LIFE SCIENCES | 1995年 / 56卷 / 18期

基金：

英国医学研究理事会;

关键词：

ACTH RECEPTOR; MUTATION; ADRENAL TUMOR;

D O I：

10.1016/0024-3205(95)00114-L

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The objective of this study was to investigate the presence of activating mutations of the ACTH receptor gene in benign and malignant adrenocortical tumour. Genomic DNA was extracted from a variety of adrenocortical neoplasms from 16 patients and the entire ACTH receptor gene was then amplified by the polymerase chain reaction and sequenced. No mutations were detected within the coding region of the ACTH receptor gene in the 16 adrenocortical tumours studied. It is likely that mutations of the coding region of the ACTH receptor gene do not play a major role in adrenocortical tumourigenesis.

引用

页码：1523 / 1527

页数：5

共 17 条

[1] ACTIVATING MUTATION IN THE STIMULATORY GUANINE-NUCLEOTIDE-BINDING PROTEIN IN AN INFANT WITH CUSHINGS-SYNDROME AND NODULAR ADRENAL-HYPERPLASIA [J].