LIPOSOME TARGETING TO MOUSE-BRAIN - MANNOSE AS A RECOGNITION MARKER

被引：115

作者：

UMEZAWA, F

ETO, Y

机构：

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1988年 / 153卷 / 03期

关键词：

D O I：

10.1016/S0006-291X(88)81333-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Liposomes prepared from lecithin:cholesterol:p-aminophenyl-alpha-mannoside (7:2:1, v/v/v) were efficiently incorporated into the mouse brain across the blood brain barrier. Furthermore, liposomes injected intraperitoneally were exclusively distributed into lysosome rich fraction and also taken up by glial cells. These data suggest that blood brain barrier cells and glial cells recognize mannose molecule on the surface of the membrane and can be used for the treatment of brain damage by lysosomal storage disease.

引用

页码：1038 / 1044

页数：7

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