POTENTIAL ANTICONVULSANTS .7. SYNTHESIS OF 5'-METHYLSPIRO[3H-INDOLE-3,2'-THIAZOLIDINE]-2,4'(1H)-DIONES

The title compounds were prepared by the cyclocondensation of thiolactic acid with isatin-3-imines. 5''-Methyl-3''-phenyl-spiro[3H-indole-3,2''-thiazolidine]-2,4''(1H)-dione was subjected to the Mannich condensation to give 1-substituted derivatives. With 1 exception, all of the products were inactive in an anticonvulsant screen.