AGING AND THE RESPONSE TO SALMONELLA INFECTION

被引：24

作者：

BRADLEY, SF ^{[1
]}

KAUFFMAN, CA ^{[1
]}

机构：

[1] UNIV MICHIGAN,SCH MED,DEPT INTERNAL MED,DIV INFECT DIS,ANN ARBOR,MI 48104

来源：

EXPERIMENTAL GERONTOLOGY | 1990年 / 25卷 / 01期

关键词：

aged rats; aging; fever; host defense; Salmonella infection;

D O I：

10.1016/0531-5565(90)90012-Q

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

We investigated the effect of age on the ability of Fischer 344 rats to mount a febrile response and contain infection due to Salmonella typhimurium. Elderly (22-23 month), middle-aged (12-13 month) and young (2-3 month) rats were inoculated intraperitoneally with 1.5 × 106 organisms and the febrile response and liver and spleen bacterial counts were followed for 13 days. The elderly had a more sluggish febrile response and did not achieve as great a maximum temperature elevation as the young and middle-aged rats. Except for days 1 and 5, bacterial counts in liver and spleen were greater in the elderly rats than in young and middle-aged rats. © 1990.

引用

页码：75 / 80

页数：6

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