COMPARISON OF NEURONAL INOSITOL 1,4,5-TRISPHOSPHATE 3-KINASE AND RECEPTOR MESSENGER-RNA DISTRIBUTIONS IN THE HUMAN BRAIN USING INSITU HYBRIDIZATION HISTOCHEMISTRY

被引：13

作者：

MAILLEUX, P ^{[1
]}

TAKAZAWA, K ^{[1
]}

ALBALA, N ^{[1
]}

ERNEUX, C ^{[1
]}

VANDERHAEGHEN, JJ ^{[1
]}

机构：

[1] UNIV LIBRE BRUXELLES,INST INTERDISCIPLINARY RES,B-1070 BRUSSELS,BELGIUM

来源：

NEUROSCIENCE LETTERS | 1992年 / 137卷 / 01期

关键词：

INSP3; 3-KINASE; RECEPTOR; HUMAN BRAIN; INSITU HYBRIDIZATION HISTOCHEMISTRY;

D O I：

10.1016/0304-3940(92)90300-V

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The distribution of the messenger RNA coding for the recently cloned inositol 1,4,5-trisphosphate (InsP3) 3-kinase, the enzyme phosphorylating InsP3 to InsP4, was compared to the localizations of InsP3 receptor mRNA in the human brain using in situ hybridization histochemistry and oligonucleotide probes. InsP3 3-kinase and receptor mRNA levels were high in the cerebellar Purkinje cells. They were also observed, to a much lesser degree than in the cerebellum, in the hippocampal CA1 pyramidal cells and dentate gyrus granule cells, in the majority of the cortical neurons and in the striatal medium-sized neurons. Both mRNAs were not detected in the brainstem and in the glial cells.

引用

页码：69 / 71

页数：3

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