A PHASE-II STUDY OF 5-FLUOROURACIL AND HIGH-DOSE FOLINIC ACID IN COMBINATION WITH CYCLOPHOSPHAMIDE AND MITOXANTRONE FOR ADVANCED BREAST-CANCER

被引：2

作者：

AITINI, E ^{[1
]}

CAVAZZINI, G ^{[1
]}

CANTORE, M ^{[1
]}

RABBI, C ^{[1
]}

RIVERA, A ^{[1
]}

TOGLIANI, B ^{[1
]}

DIMARCO, A ^{[1
]}

SMERIERI, F ^{[1
]}

机构：

[1] OSPED BORGO TRENTO,DEPT RADIAT ONCOL,VERONA,ITALY

来源：

EUROPEAN JOURNAL OF CANCER | 1992年 / 28A卷 / 12期

关键词：

D O I：

10.1016/0959-8049(92)90239-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

38 patients with advanced breast adenocarcinoma were treated in a phase II study with 5-fluorouracil and high-dose folinic acid combined with cyclophosphamide and mitoxantrone. 6 patients had received prior chemotherapy for advanced disease, all with an anthracycline-containing regimen. Treatment was generally well tolerated. The most common side-effect was myelosuppression, with 1 toxic death due to leukopenia-related sepsis. 1 patient developed severe congestive heart failure 12 months from the end of therapy. 36 patients were evaluable for response. The overall response rate was 55%. Median duration of response was 8 months and median survival time was 16 months. This regimen warrants further investigations.

引用

页码：1968 / 1970

页数：3

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