DIFFERENT MYOCARDIAL DISTRIBUTION PATTERNS BETWEEN I-123 METAIODOBENZYLGUANIDINE AND TL-201 IN HYPERTROPHIC CARDIOMYOPATHY

被引：3

作者：

FUJIWARA, Y ^{[1
]}

HAMADA, M ^{[1
]}

MUKAI, M ^{[1
]}

SHIGEMATSU, Y ^{[1
]}

SUMIMOTO, T ^{[1
]}

SEKIYA, M ^{[1
]}

HIWADA, K ^{[1
]}

HIGASHINO, H ^{[1
]}

NAKATA, S ^{[1
]}

TANADA, S ^{[1
]}

HAMAMOTO, K ^{[1
]}

机构：

[1] EHIME UNIV,SCH MED,DEPT INTERNAL MED 2,SHIGENOBU,EHIME 79102,JAPAN

来源：

AMERICAN JOURNAL OF NONINVASIVE CARDIOLOGY | 1992年 / 6卷 / 03期

关键词：

I-123; METAIODOBENZYLGUANIDINE; TL-201; HYPERTROPHIC CARDIOMYOPATHY; VENTRICULAR HYPERTROPHY; LEFT; CARDIAC ADRENERGIC INNERVATION;

D O I：

10.1159/000470353

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To elucidate the relationship between regional myocardial adrenergic innervation and left venticular hypertrophy in patients with hypertrophic cardiomyopathy (HCM), simultaneous iodine-123 metaiodobenzylguanidine (I-123-MIBG) and thallium-201 (Tl-201) myocardial scintigraphies were performed in 21 patients with HCM. In 7 patients both I-123-Tl-201 images showed a normal distribution pattern, and in 13 patients Tl-202 showed a normal distribution, but I-123-MIBG showed a low distribution or defect. Myocardial uptake of I-123-MIBG was reduced even in the segments where myocardial hypertrophy was confirmed by the echocardiographic method. The incidence of a low distribution or defect in I-123-MIBG was significantly higher in the posterior, lateral and apical segments than in the anterior and septal segments in HCM patients (each, p <0.01). The difference in the distribution pattern between I-123-MIBG and Tl-201 may reflect adrenergic nerve dysfunction. The disorder of adrenergic innervation seems to precede myocardial damage. From these findings, we conclude that a good correlation between myocardial adrenergic innervation and left ventricular hypertrophy is not necessarily observed, and the difference in distribution pattern between I-123-MIBG and Tl-201 usually takes place in the advanced stage of HCM.

引用

页码：177 / 183

页数：7