PREVALENCE OF HIV-1 AND HIV-2 MIXED INFECTIONS IN COTE-DIVOIRE

被引:80
作者
GEORGE, JR
OU, CY
PAREKH, B
BRATTEGAARD, K
BROWN, V
BOATENG, E
DECOCK, KM
机构
[1] CTR DIS CONTROL,NATL CTR INFECT DIS,DIV HIV AIDS,INT ACT,ATLANTA,GA 30333
[2] PROJECT RETROCI,ABIDJAN,COTE IVOIRE
关键词
D O I
10.1016/0140-6736(92)91406-X
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We have investigated the cause of dual serological reactivity to human immunodeficiency virus (HIV) types 1 and 2, a common occurrence in West Africa. Serum specimens from 111 individuals from cote d'Ivoire classified by commercial western blot as HIV-1 (n = 15), HIV-2 (32), and dually reactive (64) were further tested by more specific serological tests (a synthetic peptide enzyme immunoassay [Pepti-LAV 1/2] and western blots prepared from antigen in which oligomeric forms of the transmembrane protein were disrupted by trichloroacetic acid [WB-TCA]). Peripheral blood mononuclear cells were tested for HIV-1 and HIV-2 with the polymerase chain reaction (PCR) and virus culture. Of 104 samples that were concordant by both WB-TCA and Pepti-LAV, 82 (79%) were confirmed by PCR results. Virus culture was concordant with serology for specimens (35/38) in which any virus was detected. Our findings indicate that mixed HIV-1/HIV-2 infections are common in Cote d'Ivoire, and suggest that natural infection by one HIV type does not prevent heterologous infection.
引用
收藏
页码:337 / 339
页数:3
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