PROTECTIVE EFFECTS OF TETRAHYDRONEOPTERIN AGAINST FREE RADICAL-INDUCED INJURY

被引：21

作者：

ICHO, T ^{[1
]}

KOJIMA, S ^{[1
]}

SHINOHARA, N ^{[1
]}

KAJIWARA, Y ^{[1
]}

KITABATAKE, K ^{[1
]}

KUBOTA, K ^{[1
]}

机构：

[1] ASAHI BREWERY CO LTD,APPL TECHNOL RES LAB,OHTA KU,TOKYO 143,JAPAN

来源：

BIOCHEMICAL PHARMACOLOGY | 1993年 / 45卷 / 10期

关键词：

D O I：

10.1016/0006-2952(93)90003-F

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The therapeutic potency of 5,6,7,8-tetrahydroneopterin (NPH4) was investigated in ischemic paw edema, Adriamycin(R) (ADR)-induced cardiotoxicity, and endotoxin [lipopolysaccharide (LPS)]- and carbon tetrachloride (CCl4)-induced hepatotoxicity in mice. Ischemic paw edema was completely suppressed by pre-administration of NPH4. ADR-induced cardiotoxicity and LPS-induced hepatotoxicity were significantly decreased by post-administration of NPH4. Furthermore, NPH4 ameliorated CCl4-induced hepatotoxicity. These results suggest that NPH4 may be useful for the treatment of free radical, especially superoxide radical, -related tissue injury.

引用

页码：1953 / 1958

页数：6

共 37 条

[1]

ADACHI T, 1983, J PHARMACOBIO-DYNAM, V6, P114

[2]

ALLESANDRO ND, 1984, PHARMACOL RES COMMUN, V16, P145

[3] BIOLOGICAL DEFENSE MECHANISMS - PRODUCTION BY LEUKOCYTES OF SUPEROXIDE A POTENTIAL BACTERICIDAL AGENT [J].

BABIOR, BM ;

KIPNES, RS ;

CURNUTTE, JT .

JOURNAL OF CLINICAL INVESTIGATION, 1973, 52 (03) :741-744

[4]

BACHUR NR, 1977, MOL PHARMACOL, V13, P901

[5] STUDY OF RELATIONSHIPS BETWEEN CARBON TETRACHLORIDE-INDUCED LIPID PEROXIDATION AND LIVER-DAMAGE IN RATS PRETREATED WITH VITAMIN-E [J].

BENEDETTI, A ;

FERRALI, M ;

CHIELI, E ;

COMPORTI, M .

CHEMICO-BIOLOGICAL INTERACTIONS, 1974, 9 (02) :117-134

[6] ADRIAMYCIN - NEW ANTICANCER DRUG WITH SIGNIFICANT CLINICAL ACTIVITY [J].

BLUM, RH ;

CARTER, SK .

ANNALS OF INTERNAL MEDICINE, 1974, 80 (02) :249-259

[7] CELLULAR AND MOLECULAR MECHANISMS OF ACTION OF BACTERIAL-ENDOTOXINS [J].

BRADLEY, SG .

ANNUAL REVIEW OF MICROBIOLOGY, 1979, 33 :67-94

[8] PREVENTION BY CYSTAMINE OF LIVER NECROSIS AND EARLY BIOCHEMICAL ALTERATIONS INDUCED BY CARBON-TETRACHLORIDE [J].

CASTRO, JA ;

CIGNOLI, EV ;

DECASTRO, CR ;

DEFENOS, OM .

BIOCHEMICAL PHARMACOLOGY, 1972, 21 (01) :49-&

[9]

DILUZIO NR, 1973, FED PROC, V32, P1875

[10]

DROSHOW JH, 1980, J CLIN INVEST, V65, P128

← 1 2 3 4 →