MORPHOLOGICAL ASPECTS OF AN EXPERIMENTAL TUMOR PHOTOSENSITIZED WITH A MESOSUBSTITUTED CATIONIC PORPHYRIN

The meso-substituted cationic porphyrin, meso-tetra(4N-methyl-pyridyl)porphine (T(4)MP(y)P) appears to be a selective tumour localizer on the basis of pharmacokinetic studies. Irradiation (at 600-680 nm) of an intramuscularly implanted MS-2 fibrosarcoma in Balb/c mice at 24 h after injection of T(4)MP(y)P causes tumour necrosis: histological and ultrastructural analyses of tumour specimens taken at different times after phototherapy indicate slowly-appearing tissue damage which involves both malignant cells and the vascular endothelium. At the subcellular level, the membranous systems and nuclei are the main targets of the photoprocess. The tumour necrosis is particularly extensive upon injection of 4.1 mg kg(-1) T(4)MP(y)P.