A GENERAL-METHOD FOR THE SYNTHESIS OF THIOESTER RESIN LINKERS FOR USE IN THE SOLID-PHASE SYNTHESIS OF PEPTIDE-ALPHA-THIOACIDS

被引：70

作者：

CANNE, LE

WALKER, SM

KENT, SBH

机构：

[1] The Scripps Research Institute, La Jolla, CA 92037

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 08期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0040-4039(95)00037-D

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A generalized procedure for the synthesis of thioester linkers for use in stepwise solid phase peptide synthesis is reported. The linkers are compatible with Boc chemistry and, upon cleavage in HF, generate peptide C-terminal thioacids.

引用

页码：1217 / 1220

页数：4

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