FINAL ADULT HEIGHT AND ITS RELATIONSHIP TO BLOOD-GLUCOSE CONTROL AND MICROVASCULAR COMPLICATIONS IN IDDM

被引：30

作者：

PENFOLD, J ^{[1
]}

CHASE, HP ^{[1
]}

MARSHALL, G ^{[1
]}

WALRAVENS, CF ^{[1
]}

WALRAVENS, PA ^{[1
]}

GARG, SK ^{[1
]}

机构：

[1] UNIV COLORADO,HLTH SCI CTR,BARBARA DAVIS CTR CHILDHOOD DIABET,DEPT PAEDIAT,DENVER,CO 80262

来源：

DIABETIC MEDICINE | 1995年 / 12卷 / 02期

关键词：

IDDM; ADULT STATURE; GROWTH; GLYCATED HEMOGLOBIN; MICROVASCULAR COMPLICATIONS;

D O I：

10.1111/j.1464-5491.1995.tb00443.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of longitudinal blood glucose control on final adult height was evaluated in 181 subjects (94 women and 87 men) with IDDM. Diabetes onset was at a median age of 6.9 years with an interquartile range of 4.7 years. Longitudinal glycated haemoglobin values were determined over a mean period of 6.6 +/- 2.6 years during their growth phase. Serial eye and joint examinations and urinary albumin excretion rates were performed with final assessment being carried out at a mean age of 21.1 +/- 3.0 years. The mean adult height standard deviation score of the whole group was -0.22 +/- 1.15 and was reduced compared to the mean height of the general population and to the mean height of the subjects' parents and siblings. There was an inverse correlation with mean longitudinal glycated haemoglobin and final adult height (p<0.01). There was also an inverse relationship between adult height and the severity of eye, kidney, and joint complications, but when controlled by glycated haemoglobin, this relationship only remained significant for eye complications. Final adult height is reduced in subjects with early onset IDDM who remain in poor blood glucose control-during their growth period.

引用

页码：129 / 133

页数：5

共 19 条

[1]

Knowles HC, Guest GM, Lampe J., Kessler M., Skillman TG, The course of juvenile diabetes treated with unmeasured diet, Diabetes, 14, pp. 239-273, (1965)

[2]

Tattersall RB, Pyke DA, Growth in diabetic children. Studies in identical twins, Lancet, 2, pp. 1105-1109, (1973)

[3]

Grenfell A., Migdalis I., Leslie RDG, Short stature and diabetic complications, Transplant Proc, 6, (1986)

[4]

Chase HP, Jackson WE, Hoops SL, Cockerham RS, Archer PG, O'Brien D., Glucose control and the renal and retinal complications of insulin dependent diabetes, J Am Med Assoc, 261, pp. 1155-1160, (1989)

[5]

The effect of intensive treatment of diabetes on the development and progression of long‐term complications in insulin dependent diabetes, N Engl J Med, 329, pp. 977-986, (1993)

[6]

Hammill PVV, Drizd TA, Johnson CL, Reed RB, Roche AF, Moore WM, Physical growth. National Center for Health Statistics percentiles, Am J Clin Nutr, 32, pp. 607-629, (1979)

[7]

Jordan M., Staehling N., (1986)

[8]

Report 7: A modification of the Airlie House classification of diabetic retinopathy, Inv Ophth Vis Sci, 21, pp. 210-226, (1981)

[9]

Klein BE, Davis MD, Segal P., Long JA, Harris WA, Haug GA, Et al., Diabetic retinopathy: assessment of severity and progression, Ophthalmology, 91, pp. 10-17, (1984)

[10]

Garg SK, Chase HP, Marshall G., Jackson WE, Holmes D., Hoops SL, Et al., Limited joint mobility in subjects with insulin dependent diabetes mellitus: relationship with eye and kidney complications, Arch Dis Childh, 67, pp. 96-99, (1992)

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