EVIDENCE FOR THE INVOLVEMENT OF NITRIC-OXIDE IN THE ANTINOCICEPTIVE EFFECT OF KETOROLAC

被引：75

作者：

GRANADOSSOTO, V ^{[1
]}

FLORESMURRIETA, FJ ^{[1
]}

CASTANEDAHERNANDEZ, G ^{[1
]}

LOPEZMUNOZ, FJ ^{[1
]}

机构：

[1] INST POLITECN NACL,CTR INVEST & ESTUDIOS AVANZADOS,DEPT FARMACOL & TOXICOL,TERAPEUT EXPTL SECC,MEXICO CITY 14000,DF,MEXICO

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1995年 / 277卷 / 2-3期

关键词：

KETOROLAC TROMETHAMINE; NITRIC OXIDE (NO); N-G-NITRO-L-ARGININE METHYL ESTER; DIPYRONE;

D O I：

10.1016/0014-2999(95)00123-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The involvement of nitric oxide in the antinociception produced by ketorolac was assessed using the pain-induced functional impairment model in the rat: 800 mu g of N-G-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthesis, or saline was injected intra-articularly in a hind limb joint previously injured with uric acid. Animals then received ketorolac, dipyrone or no drug. Ketorolac and dipyrone produced a significant antinociceptive effect which was reduced by pretreatment with N-G-nitro-L-arginine methyl ester, but not with saline. It is concluded that the antinociceptive effect of both drugs involves the local participation of nitric oxide.

引用

页码：281 / 284

页数：4

共 15 条

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