Interaction between ionophores and biomimetic membranes

被引：4

作者：

Betrencourt, C ^{[1
]}

Hochapfel, A ^{[1
]}

Hasmonay, H ^{[1
]}

Peretti, P ^{[1
]}

Ollivon, M ^{[1
]}

GrabielleMadelmont, C ^{[1
]}

机构：

[1] UNIV PARIS SUD,URA CNRS 1218,EQUIPE PHYSICO CHIM SYST POLYPHASES,F-92296 CHATENAY MALABRY,FRANCE

来源：

MOLECULAR CRYSTALS AND LIQUID CRYSTALS SCIENCE AND TECHNOLOGY SECTION A-MOLECULAR CRYSTALS AND LIQUID CRYSTALS | 1995年 / 262卷

关键词：

D O I：

10.1080/10587259508033524

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

Insertion properties of Lasalocid and Monensin as sodium salts (LAS-Na, MON-Na) in model membranes of dipalmitoylphosphatidylcholine (DPPC) have been studied in two biomimetic buffered systems: monolayers (Langmuir Film Balance) and multilamellar bilayers (Differential Scanning Calorimetry). Effects varying with the concentration and with the surface pressure have been observed within the experimental range of molar ratios r = antibiotic / lipid from 0.005 to 0.1. The area occupied by each antibiotic molecule and the relative molecular area increase at a given pressure, are different for the two molecules. The calorimetric measurements result in concentration dependent modifications of the characteristics of the gel-liquid crystal phase transition in the case of LAS-Na. No such modifications are observed in the case of MON-Na.

引用

页码：179 / 190

页数：12

共 19 条

[1] THE ION SELECTIVITY OF NONELECTROGENIC IONOPHORES MEASURED ON A BILAYER LIPID-MEMBRANE - NIGERICIN, MONENSIN, A23187 AND LASALOCID-A [J].