Permanent renal failure induced by pentastarch

被引：10

作者：

Jamal, Rahima ^{[1
]}

Ghannoum, Marc ^{[2
]}

Naud, Jean-Francois ^{[1
]}

Turgeon, Pierre-Paul ^{[3
]}

Leblanc, Martine ^{[4
,5
]}

机构：

[1] Univ Montreal, Maisonneuve Rosemont Hosp, Dept Med, Montreal, PQ, Canada

[2] Univ Montreal, Verdun Hosp, Div Nephrol, Montreal, PQ, Canada

[3] Univ Montreal, Maisonneuve Rosemont Hosp, Dept Pathol, Montreal, PQ, Canada

[4] Univ Montreal, Maisonneuve Rosemont Hosp, Div Nephrol, Montreal, PQ, Canada

[5] Univ Montreal, Maisonneuve Rosemont Hosp, Div Crit Care, Montreal, PQ, Canada

来源：

CLINICAL KIDNEY JOURNAL | 2008年 / 1卷 / 05期

关键词：

acute renal failure; colloid; hydroxyethyl starch; pentastarch;

D O I：

10.1093/ndtplus/sfn075

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Background. Controversy exists with volume resuscitation using crystalloids or colloids. Renal dysfunction has been reported with some colloids and osmotic agents, but remains poorly defined. Patient. We report the case of a 67-year-old male who had normal kidney function at baseline and who developed anuric ARF in relation to the administration of > 10 litres of 10% pentastarch. A renal biopsy confirmed hydropic changes in tubular cells compatible with colloid-induced damage. Conclusion. This case demonstrates that hydroxyethyl starch preparations may be associated with acute kidney injury, and one should carefully consider their use, especially in patients with pre-existing renal dysfunction. Osmotic tubular cell lesions may be long lasting and irreversible.

引用

页码：322 / 325

页数：4

共 22 条

[1] INTRAVENOUS IMMUNOGLOBULIN - INDUCED OSMOTIC NEPHROSIS [J].

AHSAN, N ;

PALMER, BF ;

WHEELER, D ;

GREENLEE, RG ;

TOTO, RD .

ARCHIVES OF INTERNAL MEDICINE, 1994, 154 (17) :1985-1987

[2]

Allison KP, 1999, J TRAUMA, V14, P1517

[3] RETRACTED: Volume therapy in the critically ill: is there a difference? (Retracted article. See vol. 40, pg. 145, 2014) [J].

Boldt, J ;

Muller, M ;

Mentges, D ;

Papsdorf, M ;

Hempelmann, G .

INTENSIVE CARE MEDICINE, 1998, 24 (01) :28-36

[4] RETRACTED: Intravascular volume replacement therapy with synthetic colloids: Is there an influence on renal function? (Retracted article. See vol. 131, 2020) [J].

Boldt, J ;

Priebe, HJ .

ANESTHESIA AND ANALGESIA, 2003, 96 (02) :376-382

[5] Hydroxyethylstarch as a risk factor for acute renal failure - Is a change of clinical practise indicated? [J].

Boldt, J .

DRUG SAFETY, 2002, 25 (12) :837-846

[6] Intensive insulin therapy and pentastarch resuscitation in severe sepsis [J].

Brunkhorst, Frank M. ;

Engel, Christoph ;

Bloos, Frank ;

Meier-Hellmann, Andreas ;

Ragaller, Max ;

Weiler, Norbert ;

Moerer, Onnen ;

Gruendling, Matthias ;

Oppert, Michael ;

Grond, Stefan ;

Olthoff, Derk ;

Jaschinski, Ulrich ;

John, Stefan ;

Rossaint, Rolf ;

Welte, Tobias ;

Schaefer, Martin ;

Kern, Peter ;

Kuhnt, Evelyn ;

Kiehntopf, Michael ;

Hartog, Christiane ;

Natanson, Charles ;

Loeffler, Markus ;

Reinhart, Konrad .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (02) :125-139

[7]

CHINITZ JL, 1971, J LAB CLIN MED, V77, P76

[8] Renal impact of fluid management with colloids: a comparative review [J].

Davidson, I. J. .

EUROPEAN JOURNAL OF ANAESTHESIOLOGY, 2006, 23 (09) :721-738

[9] Acute renal failure secondary to hydroxyethylstarch administration in a surgical patient [J].

De Labarthe, A ;

Jacobs, F ;

Blot, F ;

Glotz, D .

AMERICAN JOURNAL OF MEDICINE, 2001, 111 (05) :417-418

[10]

Dickenmann MJ, 1998, NEPHROL DIAL TRANSPL, V13, P2706

← 1 2 3 →