OPTIMAL INSULIN INFUSION CONTROL VIA A MATHEMATICAL BLOOD GLUCOREGULATORY MODEL WITH FUZZY PARAMETERS

被引：15

作者：

LIM, CC

TEO, KL

机构：

[1] Department of Electrical and Electronic Engineering, The University of Adelaide South Australia

[2] Department of Mathematics, The University of Western Australia

来源：

CYBERNETICS AND SYSTEMS | 1991年 / 22卷 / 01期

关键词：

D O I：

10.1080/01969729108902267

中图分类号：

TP3 [计算技术、计算机技术];

学科分类号：

0812 ;

摘要：

In this paper, we consider a blood glucose-insulin model subject to parameter variation. Our aim is to use a mathematical optimization technique to derive insulin infusion programs for the regualtion of the blood glucose level in the case of worst possible parameter values. Numerical computation and simulation studies are carried out to verify the performance of the method on regulation of initially high blood glucose level while fasting and of blood glucose level after a meal prior to which blood glucose is at its rest level.

引用

页码：1 / 16

页数：16

共 14 条

[1]

Ackerman E., Gatewood L.C., Rosevear J.W., Molnar G.D., Model Studies of Blood Glucose Regulation, Bull. Math. Biophys, 27, pp. 21-37, (1965)

[2]

Ackerman E., Blood Glucose Regulation and Diabetes, (1969)

[3]

Campbell J.A., Albrecht P.H., An Analysis of the Control of Insulin Secretion, Proc 21St Annual Conference Eng. Med, Biol, 10, (1968)

[4]

Chisholm D.J., Kraegen E.W., Bell D.J., Chipps D.R., A Semi-Closed Loop Computer-Assisted Insulin System, Med. J. Austr, 22, pp. 784-789, (1984)

[5]

Dennis J.E., Schnabel R.B., Numerical Methods for Unconstrained Optimization and Nonlinear Equations, (1983)

[6]

Fischer U., Schenk W., Sazsieder E., Albrecht G., Abel P., Freyse E.-J., Does Physiological Blood Glucose Control Require an Adaptive Control Strategies?, IEEE Trans. Biomed. Eng., BME, 34, 8, pp. 575-582, (1987)

[7]

Fisher M.E., Teo K.L., Optimal Insulin Infusion Resulting from a Mathematical Model of Blood Glucose Dynamics, IEEE Ttans. Biomed. Eng, 36, 4, pp. 479-486, (1989)

[8]

Genuth S., Martin P., Control of Hyperglycemia in Adult Diabetics by Pulsed Insulin Delivery, Diabetes, 26, pp. 571-581, (1977)

[9]

Goh C.J., Teo K.L., MISER, an Optimal Control Software, (1987)

[10]

IMSL User Manual, 3, (1987)

← 1 2 →