ANTIMICROBIAL ACTIVITY OF BASIC CHOLANE DERIVATIVES .9.

被引：16

作者：

BELLINI, AM ^{[1
]}

MENCINI, E ^{[1
]}

QUAGLIO, MP ^{[1
]}

GUARNERI, M ^{[1
]}

FINI, A ^{[1
]}

机构：

[1] IST SCI CHIM,I-40127 BOLOGNA,ITALY

来源：

ARCHIV DER PHARMAZIE | 1990年 / 323卷 / 04期

关键词：

D O I：

10.1002/ardp.19903230404

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Twenty new compounds derived from deoxycholic acid have been synthesized. They contain two basic functions: at C‐24 (benzylamino, morpholino, diethanolamino, N,N‐diethylethylenediamino, N‐methylpiperazino) and at β‐C‐3 (amino, methylamino, ethylamino, benzylamino). The compounds showed interesting antimicrobial activity, as expressed in terms of the low M.I.C. values (0.9‐31‐μ/ml) against five Gram(+) and four Gram(−) strains, two fungi and one yeast. The compounds inhibit the production of a fluorescent pigment in Pseudomonas aeruginosa: this result suggests that the ability to cross the bacterium cell membrane is the first step of activity. A discussion in terms of structure‐activity relationship is reported. Copyright © 1990 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim

引用

页码：201 / 205

页数：5

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