SYNTHESIS OF N29-DESMETHYL RA-VII - IDENTIFICATION OF THE PHARMACOPHORE OF RA-I-VII AND DEOXYBOUVARDIN AND REASSIGNMENT OF THE SUBUNIT FUNCTIONAL ROLES

被引：35

作者：

BOGER, DL ^{[1
]}

YOHANNES, D ^{[1
]}

MYERS, JB ^{[1
]}

机构：

[1] PURDUE UNIV,DEPT MED CHEM,W LAFAYETTE,IN 47907

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 05期

关键词：

D O I：

10.1021/jo00031a001

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N29-Desmethyl RA-VII was prepared in efforts that address the key structural and conformational features of the agent that contribute to its antitumor activity.

引用

页码：1319 / 1321

页数：3

共 22 条

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[7] INTRAMOLECULAR ULLMANN CONDENSATION REACTION - AN EFFECTIVE APPROACH TO MACROCYCLIC DIARYL ETHERS
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[9] EVALUATION OF BOUVARDIN, DEOXYBOUVARDIN, AND RA-I - RA-VII PARTIAL STRUCTURES - REASSIGNMENT OF THE PHARMACOPHORE
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