DETECTION OF ENDOGENOUS MALONDIALDEHYDE-DEOXYGUANOSINE ADDUCTS IN HUMAN LIVER

被引:407
作者
CHAUDHARY, AK
NOKUBO, M
REDDY, GR
YEOLA, SN
MORROW, JD
BLAIR, IA
MARNETT, LJ
机构
[1] VANDERBILT UNIV,SCH MED,AB HANCOCK JR MEM LAB CANC RES,NASHVILLE,TN 37232
[2] VANDERBILT UNIV,SCH MED,DEPT BIOCHEM,NASHVILLE,TN 37232
[3] VANDERBILT UNIV,SCH MED,DEPT PHARMACOL,NASHVILLE,TN 37232
关键词
D O I
10.1126/science.8079172
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Endogenous DNA adducts may contribute to the etiology of human genetic disease and cancer. One potential source of endogenous DNA adducts is lipid peroxidation, which generates mutagenic carbonyl compounds such as malondialdehyde. A sensitive mass spectrometric method permitted detection and quantitation of the major malondialdehyde-DNA adduct, a pyrimidopurinone derived from deoxyguanosine. DNA from disease-free human liver was found to contain 5400 adducts per cell, a frequency comparable to that of adducts formed by exogenous carcinogens.
引用
收藏
页码:1580 / 1582
页数:3
相关论文
共 31 条
  • [1] ENDOGENOUS MUTAGENS AND THE CAUSES OF AGING AND CANCER
    AMES, BN
    GOLD, LS
    [J]. MUTATION RESEARCH, 1991, 250 (1-2): : 3 - 16
  • [2] UNEQUIVOCAL DEMONSTRATION THAT MALONDIALDEHYDE IS A MUTAGEN
    BASU, AK
    MARNETT, LJ
    [J]. CARCINOGENESIS, 1983, 4 (03) : 331 - 333
  • [3] BENAMIRA M, IN PRESS CARCINOGENE
  • [4] BERNHEIM F, 1948, J BIOL CHEM, V174, P257
  • [5] PROOXIDANT STATES AND TUMOR PROMOTION
    CERUTTI, PA
    [J]. SCIENCE, 1985, 227 (4685) : 375 - 381
  • [6] Chaudhary A, UNPUB
  • [7] METABOLISM OF POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVES TO ULTIMATE CARCINOGENS DURING LIPID-PEROXIDATION
    DIX, TA
    MARNETT, LJ
    [J]. SCIENCE, 1983, 221 (4605) : 77 - 79
  • [8] MECHANISMS AND BIOLOGICAL RELEVANCE OF LIPID-PEROXIDATION INITIATION
    DIX, TA
    AIKENS, J
    [J]. CHEMICAL RESEARCH IN TOXICOLOGY, 1993, 6 (01) : 2 - 18
  • [9] Esterbauer H., 1982, FREE RADICAL LIPID P, P101
  • [10] THE HUMAN MUTATOR GENE HOMOLOG MSH2 AND ITS ASSOCIATION WITH HEREDITARY NONPOLYPOSIS COLON-CANCER
    FISHEL, R
    LESCOE, MK
    RAO, MRS
    COPELAND, NG
    JENKINS, NA
    GARBER, J
    KANE, M
    KOLODNER, R
    [J]. CELL, 1993, 75 (05) : 1027 - 1038