CLONING OF A SYRIAN-HAMSTER CDNA RELATED TO SEXUAL DIMORPHISM - ESTABLISHMENT OF A NEW FAMILY OF PROTEINS

被引：32

作者：

DOMINGUEZ, P

机构：

[1] Departamento de Bioquímica y Biologia Molecular, Facultad de Medicina, Universidad de Oviedo

来源：

FEBS LETTERS | 1995年 / 376卷 / 03期

关键词：

SEXUAL DIMORPHISM; SUBTRACTIVE CLONING; HARDERIAN GLAND; STEROID BINDING; SYRIAN HAMSTER;

D O I：

10.1016/0014-5793(95)01294-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The clone FHG22, isolated from a female minus male subtracted cDNA library obtained from the sexually dimorphic Syrian hamster Harderian glands (HG) is 440 bp long with a 95 amino acids ORF, and hybridizes to a female HG-specific 0.6 kb mRNA. The FHG22 nucleotide and amino acid sequences are similar to the subunits from prostatein, uteroglobin, major cat allergen Fel dI (chain 1) and mouse salivary androgen binding proteins (subunit alpha). Therefore I propose that all those polypeptides belong to a common new family. The hamster genome has a single copy of the FHG22 gene, without homologous genes. PHG22 mRNA is also found in male and female parotid (higher levels in females) and submandibular glands, indicating a tissue and sex-dependent control of expression.

引用

页码：257 / 261

页数：5

共 45 条

[1]

ANDERSSON O, 1994, J BIOL CHEM, V269, P19081

[2] PORPHYRIN ACCUMULATION IN THE HARDERIAN GLANDS OF FEMALE SYRIAN-HAMSTER RESULTS IN MITOCHONDRIAL DAMAGE AND CELL-DEATH [J].