THE GENOME RECONSTRUCTION MANAGER - A SOFTWARE ENVIRONMENT FOR SUPPORTING HIGH-THROUGHPUT DNA-SEQUENCING

被引：13

作者：

LAWRENCE, CB

HONDA, S

PARROTT, NW

FLOOD, TC

GU, LH

ZHANG, L

JAIN, M

LARSON, S

MYERS, EW

机构：

[1] BAYLOR COLL MED, DEPT MOLEC & HUMAN GENET, HOUSTON, TX 77030 USA

[2] UNIV ARIZONA, DEPT COMP SCI, TUCSON, AZ 85721 USA

来源：

GENOMICS | 1994年 / 23卷 / 01期

关键词：

D O I：

10.1006/geno.1994.1477

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new software system designed for use in high-throughput DNA sequencing laboratories is described. The Genome Reconstruction Manager (GRM) was developed from requirements derived from ongoing large-scale DNA sequencing projects. Object-oriented principles were followed in designing the system, and tools supporting object-oriented system development were employed for its implementation. GRM provides several advances in software support for high-throughput DNA sequencing: support for random, directed, and mixed sequencing strategies; a novel system for fragment assembly; a commercial object database management system for data storage; a client/server architecture for using network computational servers; and an underlying data model that can evolve to support fully automatic sequence reconstruction. GRM is currently being deployed for production use in high-throughput DNA sequencing projects. (C) 1994 Academic Press, Inc.

引用

页码：192 / 201

页数：10

共 26 条

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