DNA-FINGERPRINTING BY HYBRIDIZATION TO OLIGONUCLEOTIDE ARRAYS

被引：21

作者：

SOUTHERN, EM

机构：

[1] Department of Biochemistry, University of Oxford

来源：

ELECTROPHORESIS | 1995年 / 16卷 / 09期

关键词：

DNA FINGERPRINTING; HYBRIDIZATION TO OLIGONUCLEOTIDE ARRAYS; FORENSIC SCIENCE;

D O I：

10.1002/elps.11501601256

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Most methods for analysing variation in DNA sequences rely on gel electrophoresis, a method which is difficult to automate and to quantify. Hybridisation to oligonucleotides bound to a solid surface offers alternatives, with the advantage that they can be more readily automated and lend themselves to powerful statistical analytical procedures. In this paper, we discuss a number of different ways in which oligonucleotide arrays could be used for DNA typing for applications in forensic science.

引用

页码：1539 / 1542

页数：4

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