COMMERCIAL SYNTHESIS OF ALPHA-D-CELLOBIOSYL BROMIDE HEPTAACETATE

被引：6

作者：

GOGGIN, KD ^{[1
]}

HAMMEN, PD ^{[1
]}

KNUTSON, KL ^{[1
]}

LAMBERT, JF ^{[1
]}

WALINSKY, SW ^{[1
]}

WATSON, HA ^{[1
]}

机构：

[1] PFIZER INC,DIV CENT RES,GROTON,CT 06340

来源：

JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY | 1994年 / 60卷 / 03期

关键词：

ALPHA-D-CELLOBIOSYL BROMIDE HEPTAACETATE; ACETOBROMO-ALPHA-D-CELLOBIOSE; HBR BROMINATION OF ALPHA-CELLOBIOSE OCTAACETATE;

D O I：

10.1002/jctb.280600305

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A detailed commercial process for the synthesis and purification of the activated disaccharide, alpha-D-cellobiosyl bromide heptaacetate (1) was developed. Reaction Of alpha-D-cellobiose octaacetate (CBO) with HBr in glacial acetic acid or in glacial acetic acid/methylene chloride combination affords alpha-D-cellobiosyl bromide heptaacetate in high yield and excellent quality. Process variables such as reaction solvent, reaction time, reaction temperature, HBr stoichiometry, isolation methods and product purification options were optimized for large-scale synthesis. Alpha-D-cellobiosyl bromide heptaacetate was successfully prepared in a commercial manufacturing plant.

引用

页码：253 / 256

页数：4

共 16 条

[1] DEOXY-SUGARS .5. A REINVESTIGATION OF THE GLYCAL METHOD FOR THE SYNTHESIS OF 2-DEOXY-D-RIBOSE AND 2-DEOXY-L-RIBOSE [J].