TREATMENT OF SICKLE-CELL-ANEMIA WITH 5-AZACYTIDINE RESULTS IN INCREASED FETAL HEMOGLOBIN PRODUCTION AND IS ASSOCIATED WITH NONRANDOM HYPOMETHYLATION OF DNA AROUND THE GAMMA-DELTA-BETA-GLOBIN GENE-COMPLEX

被引：261

作者：

CHARACHE, S

DOVER, G

SMITH, K

TALBOT, CC

MOYER, M

BOYER, S

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT PEDIAT,BALTIMORE,MD 21205

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT LAB MED,BALTIMORE,MD 21205

[3] HOWARD HUGHES MED INST,HUMAN BIOCHEM GENET LAB,BALTIMORE,MD 21205

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES | 1983年 / 80卷 / 15期

关键词：

D O I：

10.1073/pnas.80.15.4842

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

收藏

页码：4842 / 4846

页数：5

相关论文

共 38 条

[1] BENEDICT WF, 1977, CANCER RES, V37, P2202
[2] HEMOGLOBIN INTERACTION - MODIFICATION OF SOLID PHASE COMPOSITION IN SICKLING PHENOMENON
BERTLES, JF
RABINOWITZ, R
DOBLER, J
[J]. SCIENCE, 1970, 169 (3943) : 375 - +
[3] LOSS OF RDNA METHYLATION ACCOMPANIES THE ONSET OF RIBOSOMAL GENE ACTIVITY IN EARLY DEVELOPMENT OF X-LAEVIS
BIRD, A
TAGGART, M
MACLEOD, D
[J]. CELL, 1981, 26 (03) : 381 - 390
[4] POST-SYNTHETIC DEAMIDATION OF HEMOGLOBIN PROVIDENCE (BETA-82 LYS-]ASN ASP) AND ITS EFFECT ON OXYGEN-TRANSPORT
CHARACHE, S
FOX, J
MCCURDY, P
KAZAZIAN, H
WINSLOW, R
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1977, 59 (04) : 652 - 658
[5] CHARACHE S, 1981, BLOOD, V58, P892
[6] TOXIC-THERAPEUTIC RATIO OF SODIUM CYANATE
CHARACHE, S
DUFFY, TP
JANDER, N
SCOTT, JC
BEDINE, M
MORRELL, R
[J]. ARCHIVES OF INTERNAL MEDICINE, 1975, 135 (08) : 1043 - 1047
[7] EXPRESSION OF TRANSFERRED THYMIDINE KINASE GENES IS CONTROLLED BY METHYLATION
CHRISTY, B
SCANGOS, G
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (20): : 6299 - 6303
[8] DNA METHYLATION CONTROLS THE INDUCIBILITY OF THE MOUSE METALLOTHIONEIN-I GENE IN LYMPHOID-CELLS
COMPERE, SJ
PALMITER, RD
[J]. CELL, 1981, 25 (01) : 233 - 240
[9] FUNCTIONAL STRIATED-MUSCLE CELLS FROM NON-MYOBLAST PRECURSORS FOLLOWING 5-AZACYTIDINE TREATMENT
CONSTANTINIDES, PG
JONES, PA
GEVERS, W
[J]. NATURE, 1977, 267 (5609) : 364 - 366
[10] CREUSOT F, 1982, J BIOL CHEM, V257, P2041

← 1 2 3 4 →