SALMON PANCREATIC-POLYPEPTIDE EXHIBITS NEUROPEPTIDE-Y-LIKE ACTIVITIES IN RATS

被引:17
作者
BALASUBRAMANIAM, A
RIGEL, DF
CHANCE, WT
STEIN, M
FISCHER, JE
KING, D
PLISETSKAYA, EM
机构
[1] VET AFFAIRS MED CTR,CINCINNATI,OH 45267
[2] UNIV CINCINNATI,MED CTR,DEPT PHARMACOL & CELL BIOPHYS,CINCINNATI,OH 45267
[3] UNIV CALIF BERKELEY,DEPT MOLEC & CELL BIOL,BERKELEY,CA 94720
[4] UNIV WASHINGTON,DEPT ZOOL,SEATTLE,WA 98195
关键词
Feeding; Neuropeptide Y; Pancreatic polypeptide; Solid phase synthesis; Vasoconstrictor activity;
D O I
10.1016/0196-9781(90)90178-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Salmon pancreatic polypeptide (sPP) is a 36 residue peptide amide isolated from salmon pancreas. It has 83% sequence identity with porcine neuropeptide Y (NPY). To confirm the sequence and obtain sufficient quantity of peptide for biological investigations, sPP was synthesized by automated t-Boc solid phase synthesis. The purified product had the expected amino acid composition, primary structure and mass, and was chemically and biologically indistinguishable from natural sPP. Investigation of its biological properties revealed that, like NPY, sPP increased blood pressure and decreased heart rate in anesthetized rats in a dose-dependent manner. There was no significant difference in the responses of NPY and sPP. Furthermore, administration of sPP directly into the hypothalamus of rats induced a feeding response comparable to that induced by NPY. Based on these investigations it may be suggested that synthetic and natural sPP are identical, and that sPP can express NPY-like activities in mammals presumably by interacting with the receptors of NPY. © 1990.
引用
收藏
页码:673 / 677
页数:5
相关论文
共 28 条
  • [1] A NONAMIDATED PEPTIDE HOMOLOGOUS TO PORCINE PEPTIDE-YY AND NEUROPEPTIDE-YY
    ANDREWS, PC
    HAWKE, D
    SHIVELY, JE
    DIXON, JE
    [J]. ENDOCRINOLOGY, 1985, 116 (06) : 2677 - 2681
  • [2] BALASUBRAMANIAM A, 1987, INT J PEPT PROT RES, V29, P78
  • [3] SYNTHESIS AND BIOLOGICAL PROPERTIES OF 4-NORLEUCINE-NEUROPEPTIDE-Y - SECONDARY STRUCTURE OF NEUROPEPTIDE-Y
    BALASUBRAMANIAM, A
    RENUGOPALAKRISHNAN, V
    RIGEL, DF
    NUSSBAUM, MS
    RAPAKA, RS
    DOBBS, JC
    CARREIRA, LA
    FISCHER, JE
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1989, 997 (03) : 176 - 181
  • [4] GLYCINE-EXTENDED ANGLERFISH PEPTIDE YG (APY) A NEUROPEPTIDE-Y (NPY) HOMOLOG MAY BE A PRECURSOR OF A BIOLOGICALLY-ACTIVE PEPTIDE
    BALASUBRAMANIAM, A
    ANDREWS, PC
    RENUGOPALAKRISHNAN, V
    RIGEL, DF
    [J]. PEPTIDES, 1989, 10 (03) : 581 - 585
  • [5] BALASUBRAMANIAM A, 1988, Peptide Research, V1, P32
  • [6] BALASUBRAMANIAM A, 1989, 11TH AM PEPT S, P228
  • [7] NEUROPEPTIDE-Y (NPY) MODULATES INVITRO GONADOTROPIN IN RELEASE FROM RAINBOW-TROUT PITUITARY-GLANDS
    BRETON, B
    MIKOLAJCZYK, T
    DANGER, JM
    GONNET, F
    SAINTPIERRE, S
    VAUDRY, H
    [J]. FISH PHYSIOLOGY AND BIOCHEMISTRY, 1989, 7 (1-6) : 77 - 83
  • [8] PERTUSSIS TOXIN INHIBITS NEUROPEPTIDE Y-INDUCED FEEDING IN RATS
    CHANCE, WT
    SHERIFF, S
    FOLEYNELSON, T
    FISCHER, JE
    BALASUBRAMANIAM, A
    [J]. PEPTIDES, 1989, 10 (06) : 1283 - 1286
  • [9] NEUROPEPTIDE-Y (NPY) BINDING-SITES IN RAT-BRAIN LABELED WITH I-125 BOLTON-HUNTER NPY - COMPARATIVE POTENCIES OF VARIOUS POLYPEPTIDES ON BRAIN NPY BINDING AND BIOLOGICAL RESPONSES IN THE RAT VASDEFERENS
    CHANG, RSL
    LOTTI, VJ
    CHEN, TB
    CERINO, DJ
    KLING, PJ
    [J]. LIFE SCIENCES, 1985, 37 (22) : 2111 - 2122
  • [10] NEUROPEPTIDE Y (NPY)-INDUCED FEEDING-BEHAVIOR IN FEMALE RATS - COMPARISON WITH HUMAN NPY ([MET17]NPY), NPY ANALOG ([NORLEU4]NPY) AND PEPTIDE-YY
    CLARK, JT
    SAHU, A
    KALRA, PS
    BALASUBRAMANIAM, A
    KALRA, SP
    [J]. REGULATORY PEPTIDES, 1987, 17 (01) : 31 - 39