CHARACTERIZATION OF A HUMAN TAR RNA-BINDING PROTEIN THAT ACTIVATES THE HIV-1 LTR

被引：361

作者：

GATIGNOL, A ^{[1
]}

BUCKLERWHITE, A ^{[1
]}

BERKHOUT, B ^{[1
]}

JEANG, KT ^{[1
]}

机构：

[1] NIAID,MOLEC MICROBIOL LAB,BETHESDA,MD 20892

来源：

SCIENCE | 1991年 / 251卷 / 5001期

关键词：

D O I：

10.1126/science.2011739

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Human immunodeficiency virus type 1 (HIV-1) gene expression is activated by Tat, a virally encoded protein. Tat trans-activation requires viral (trans-activation-responsive; TAR) RNA sequences located in the R region of the long terminal repeat (LTR). Existing evidence suggests that Tat probably cooperates with cellular factors that bind to TAR RNA in the overall trans-activation process. A HeLa complementary DNA was isolated and characterized that encodes a TAR RNA-binding protein (TRBP). TRBP activated the HIV-1 LTR and was synergistic with Tat function.

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页码：1597 / 1600

页数：4

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