MICELLAR-MEDIATED SHIFTS OF IONIZATION-CONSTANTS OF AMINO-ACIDS AND PEPTIDES

被引：50

作者：

KHALEDI, MG

RODGERS, AH

机构：

[1] Department of Chemistry, North Carolina State University, Raleigh, NC 27695-8204

来源：

ANALYTICA CHIMICA ACTA | 1990年 / 239卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Amino acids; Peptides;

D O I：

10.1016/S0003-2670(00)83842-8

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The acid-base dissociation constants, Ka, of amino acids and small peptides were determined in both aqueous and micellar solutions of sodium dodecyl sulfate and cetyltrimethylammonium bromide by potentiometric and chromatographic means. The observed differences in pKa values between micellar media and aqueous solutions ranged between 0.23 and 2.21 units. The micellar-mediated pKa shifts can be attributed to different solute-micelle interactions, mainly hydrophobic and electrostatic forces. The implications of the change in acid-base behavior on separation selectivity in micellar liquid chromatography and micellar electrokinetic capillary chromatography are discussed. © 1990.

引用

页码：121 / 128

页数：8

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