SYNTHESIS OF (C-11)-SUBSTITUTED ANALOGS OF 1-ALPHA,25-DIHYDROXYVITAMIN-D3

被引：10

作者：

DHALLEWEYN, C ^{[1
]}

VANHAVER, D ^{[1
]}

VANDEREYCKEN, J ^{[1
]}

DECLERCQ, P ^{[1
]}

VANDEWALLE, M ^{[1
]}

机构：

[1] STATE UNIV GHENT,ORGAN SYNTH LAB,KRIJGSLAAN 281 S4,B-9000 GHENT,BELGIUM

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(00)80173-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of a series of C-ring modified analogues of 1-alpha,25-dihydroxyvitamin D3, with various alpha- and beta-oriented substituents on C-11, is described. It includes the construction of the 25-hydroxylated side-chain, the stereoselective introduction of the substituents at C-11 via conjugate organocuprate addition, and coupling with the A-ring.

引用

页码：477 / 480

页数：4

共 17 条

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