SYNTHESIS OF 5'-O-NUCLEOSIDE AND 3'-O-NUCLEOSIDE CARBAMATES

被引：19

作者：

GARCIAALLES, LF ^{[1
]}

GOTOR, V ^{[1
]}

机构：

[1] UNIV OVIEDO,FAC QUIM,DEPT QUIM ORGAN & INORGAN,E-33071 OVIEDO,SPAIN

来源：

TETRAHEDRON | 1995年 / 51卷 / 01期

关键词：

D O I：

10.1016/0040-4020(94)00948-T

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The two step synthesis of 5'-O- and 3'-O-(N-alkylcarbamoyl)-nucleosides is described. The key step is the enzymatic synthesis of 5'-O- or 3'-O-alkoxycarbonylnucleoside in a regioselective way. In a second aminolysis step these carbonates yield the corresponding urethanes. This methodology allows to assemble aminoalcohols and L-amino acids to 2'-deoxynucleosides.

引用

页码：307 / 316

页数：10

共 18 条

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