2 TUMOR-NECROSIS-FACTOR RECEPTORS - STRUCTURE AND FUNCTION

被引：713

作者：

VANDENABEELE, P ^{[1
]}

DECLERCQ, W ^{[1
]}

BEYAERT, R ^{[1
]}

FIERS, W ^{[1
]}

机构：

[1] VIB KL,B-9000 GHENT,BELGIUM

来源：

TRENDS IN CELL BIOLOGY | 1995年 / 5卷 / 10期

关键词：

D O I：

10.1016/S0962-8924(00)89088-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Tumour necrosis factor (TNF) exerts two main effects: a beneficial one as an anti-infection, anti-tumour cytokine, and a detrimental one in the systemic inflammatory response syndrome (SIRS). Two receptors (TNF-R) mediate these effects, but their precise role in different cell types is far from solved. TNF induces receptor oligomerization, an event that is believed to connect the receptors to downstream signalling pathways. Recent research suggests that several TNF-R-associated proteins, including kinases, may initiate cytoplasmic signal transduction.

引用

页码：392 / 399

页数：8

共 78 条

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