CIRCULATORY ALTERATIONS INDUCED BY INTRAARTERIAL INJECTION OF IODIZED OIL AND EMULSIONS OF IODIZED OIL AND DOXORUBICIN - EXPERIMENTAL-STUDY

被引:72
作者
DEBAERE, T [1 ]
DUFAUX, J [1 ]
ROCHE, A [1 ]
COUNNORD, JL [1 ]
BERTHAULT, MF [1 ]
DENYS, A [1 ]
PAPPAS, P [1 ]
机构
[1] UNIV PARIS, BIORHEOL & PHYSIOCOCHEM HYDRODYNAM LAB, PARIS, FRANCE
关键词
CONTRAST MEDIA; FATTY ACID; DOXORUBICIN; HEPATIC ARTERIES; THERAPEUTIC BLOCKADE; LIVER NEOPLASMS; CHEMOTHERAPEUTIC INFUSION;
D O I
10.1148/radiology.194.1.7997545
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
PURPOSE: To evaluate circulatory alterations induced by intra-arterial injection of iodized oil and emulsions of iodized oil with an anticancer drug. MATERIALS AND METHODS: The viscosities and stability were evaluated in arterial flow of iodized oil and the emulsions. Doppler ultrasound was used to quantify the embolic effect in the arteries of rabbits. The behavior of doxorubicin and iodized oil in the rat cremaster muscle was studied with videomicroscopy. RESULTS: The emulsions did not break up after injection, and the size of discontinuous-phase droplets did not change. The embolic effect did not correlate with viscosity. The thinnest water-in-oil emulsion had the lowest embolic effect and induced homogeneous distribution of iodized oil droplets in the arterial tree. CONCLUSION: Changes in the formulation of emulsions obtained with the same proportions of drug and iodized oil change the distribution of iodized oil in the arterial tree, the location at which the drug is released, and the embolic effect.
引用
收藏
页码:165 / 170
页数:6
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