SPONTANEOUS DEAMIDATION OF A PROTEIN ANTIBIOTIC, NEOCARZINOSTATIN, AT WEAKLY ACIDIC PH - CONVERSION TO A HOMOLOGOUS INACTIVE PRENEOCARZINOSTATIN DUE TO CHANGE OF ASPARAGINE 83 TO ASPARTIC-ACID 83 ACCOMPANIED BY CONFORMATIONAL AND BIOLOGICAL ALTERATIONS

被引：29

作者：

MAEDA, H

KUROMIZU, K

机构：

[1] KUMAMOTO UNIV,SCH MED,DEPT MICROBIOL,KUMAMOTO 860,JAPAN

[2] FUKUOKA DENT COLL,DEPT CHEM,NISHI KU,FUKUOKA 814,JAPAN

来源：

JOURNAL OF BIOCHEMISTRY | 1977年 / 81卷 / 01期

关键词：

D O I：

10.1093/oxfordjournals.jbchem.a131443

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：25 / 35

页数：11

共 38 条

[1] ACCELERATED CHROMATOGRAPHIC ANALYSIS OF AMINO ACIDS IN PHYSIOLOGICAL FLUIDS CONTAINING GLUTAMINE AND ASPARAGINE [J].

BENSON, JV ;

GORDON, MJ ;

PATTERSON, JA .

ANALYTICAL BIOCHEMISTRY, 1967, 18 (02) :228-+

[2]

DELANGE RJ, 1971, ENZYMES, V3, P102

[3] ON HETEROGENEITY OF BEEF HEART CYTOCHROME C .3. A KINETIC STUDY OF NON-ENZYMIC DEAMIDATION OF MAIN SUBFRACTIONS (CY I - CY 3) [J].

FLATMARK, T .

ACTA CHEMICA SCANDINAVICA, 1966, 20 (06) :1487-&

[4]

Greenstein JD, 1961, CHEM AMINO ACIDS, P925

[5]

HAGLUND H, 1971, METHODS BIOCH ANAL, V19, P64

[6]

HOARE DG, 1967, J BIOL CHEM, V242, P2447

[7]

ISHIDA N, 1965, J ANTIBIOT, V18, P68

[8] PRE-NEOCARZINOSTATIN, A SPECIFIC ANTAGONIST OF NEOCARZINOSTATIN [J].

KIKUCHI, M ;

SHOJI, M ;

ISHIDA, N .

JOURNAL OF ANTIBIOTICS, 1974, 27 (10) :766-774

[9] BIOGENESIS OF AN ANTITUMOR ANTIBIOTIC PROTEIN, NEOCARZINOSTATIN [J].

KUDO, K ;

KIKUCHI, M ;

ISHIDA, N .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1972, 1 (04) :289-&

[10]

LEGGETTBAILEY J, 1967, TECHNIQUES PROTEIN C, P342

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