THE CRITICAL CONCENTRATION OF SURFACTANT IN FETAL LUNG LIQUID AT BIRTH

被引:42
作者
KOBAYASHI, T [1 ]
SHIDO, A [1 ]
NITTA, K [1 ]
INUI, S [1 ]
GANZUKA, M [1 ]
ROBERTSON, B [1 ]
机构
[1] ST GORANS UNIV HOSP,EXPTL PERINATAL PATHOL RES UNIT,S-11281 STOCKHOLM,SWEDEN
来源
RESPIRATION PHYSIOLOGY | 1990年 / 80卷 / 2-3期
关键词
Animal; rabbit; Fetal lung liquid; Neonatal lung; surfactant; Surfactant;
D O I
10.1016/0034-5687(90)90082-A
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Various doses (0-4.8 mg) of porcine surfactant were administered into the airways of immature newborn rabbits delivered at a gestational age of 26 days and 17-23 h. When the estimated concentration of exogenous surfactant in the lung liquid was ≤0.75 mg/ml (dose 0.6 mg), an average tidal volume of no more than a 3.0 ml/kg was obtained by mechanical ventilation with a peak insufflation pressure of 25 cm H2O, but when the estimated concentration was increased to 1.5 mg/ml (dose 1.2 mg), an average tidal volume of 17.7 ml/kg was attained, and the survival rate during a 30-min period of artificial ventilation improved significantly, from 14% to 53%. Even larger average tidal volumes, about 25 ml/kg, were recorded in animals with estimated surfactant concentrations of 3 and 6 mg/ml (doses 2.4 and 4.8 mg, respectively). In vitro observations revealed that the surface adsorption time of the surfactant suspension decreased non-linearity from 20 to 1 sec when the concentration was increased from 1 to 3 mg/ml. The minimum surface tension during cyclic film compression also decreased non-linearity from >15 to <3 mN/m with the same increments in concentrations. This led us to conclude that, under the present experimental conditions, the critical concentration of surfactant in fetal lung liquid at birth (about 3 mg/ml) is close to the concentration required in vitro for rapid adsorption and optimal dynamic surface properties. © 1990.
引用
收藏
页码:181 / 192
页数:12
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