DETERMINATION OF SOME BETA-BLOCKERS AS DABSYL DERIVATIVES BY HPLC

被引：15

作者：

ALPERTUNGA, B ^{[1
]}

SUNGUR, S ^{[1
]}

ERSOY, L ^{[1
]}

MANAV, SY ^{[1
]}

机构：

[1] UNIV YILDIZ,FAC SCI & ARTS,ISTANBUL 80270,TURKEY

来源：

ARCHIV DER PHARMAZIE | 1990年 / 323卷 / 09期

关键词：

D O I：

10.1002/ardp.19903230906

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A HPLC method has been developed that permits the sensitive determination of beta adrenergic blocking drugs, including acebutolol, metoprolol, oxprenolol, pindolol, and propranolol. These compounds were converted to their chromophoric dabsyl derivatives and were separated by a reversed phase chromatographic column (μ.‐Bondapak C18) with methanol‐water (75:25) as isocratic mobile phase. The derivatives were detected by a variable wavelength dedector operating at 430 nm. The method was applied to commercial pharmaceutical preparations and the results were statistically compared with those obtained by official methods using t‐ and F‐tests. Copyright © 1990 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim

引用

页码：587 / 589

页数：3

共 20 条

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