PROJECTIONS FROM THE VENTROMEDIAL NUCLEUS OF THE HYPOTHALAMUS CONTAIN OXYTOCIN BINDING-SITES

被引:8
作者
JOHNSON, AE
HARBAUGH, CR
GELHARD, RE
机构
[1] KAROLINSKA INST,HUDDINGE HOSP,CLIN RES CTR,DIV MED CELL & NEUROBIOL,S-14104 HUDDINGE,SWEDEN
[2] NIMH,CLIN SCI LAB,COMPARAT STUDIES BRAIN BEHAV SECT,POOLESVILLE,MD 20837
关键词
OXYTOCIN RECEPTOR; ESTRADIOL; VENTROMEDIAL HYPOTHALAMUS; VENTROMEDIAL HYPOTHALAMIC NUCLEUS; ELECTROLYTIC LESION; I-125-D(CH2)5[TYR(ME)2; THR4; TYR-NH2(9)]OVT; RECEPTOR AUTORADIOGRAPHY;
D O I
10.1016/0006-8993(91)90815-D
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Experiments were conducted to determine the source of steroid-dependent oxytocin (OT) receptors that surround the ventrolateral portion of the ventromedial hypothalamic nucleus (vl-VMN). Ovariectomized rats received sham or unilateral electrolytic lesions of the vl-VMN. Three days later and for the next 4 days, animals were injected with 10-mu-g of estradiol benzoate (EB). OT receptors were labelled with I-125-d(CH2)5[Tyr(Me)2,Thr4,Tyr-NH2(9)]OVT and binding was assessed with autoradiographic methods. Lesions of the vl-VMN reduced OT receptor binding in the area surrounding the nucleus by over 80% indicating that the majority of OT receptors in the ventromedial hypothalamus are located on fibers originating within the VMN.
引用
收藏
页码:332 / 336
页数:5
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