ENANTIOSELECTIVE OXIDATIONS OF SULFIDES CATALYZED BY CHLOROPEROXIDASE

被引：139

作者：

COLONNA, S

GAGGERO, N

MANFREDI, A

CASELLA, L

GULLOTTI, M

CARREA, G

PASTA, P

机构：

[1] UNIV MILAN,CTR CNR,DIPARTIMENTO CHIM INORGAN & MET ORGAN,I-20122 MILAN,ITALY

[2] CNR,IST CHIM ORMONI,I-20133 MILAN,ITALY

来源：

BIOCHEMISTRY | 1990年 / 29卷 / 46期

关键词：

D O I：

10.1021/bi00498a006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The chloroperoxidase-catalyzed and horseradish peroxidase catalyzed oxidations of sulfides by tert-butyl and other peroxides have been investigated. The former metal enzyme afforded the corresponding sulfoxides having R absolute configuration in up to 92% enantiomeric excess (ee), whereas the latter gave racemic products. The various factors that control the enantioselectivity of the oxygenation have been examined. © 1990, American Chemical Society. All rights reserved.

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页码：10465 / 10468

页数：4

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