INHIBITORY EFFECT OF STREPTOZOTOCIN ON TUMOR-DEVELOPMENT IN TRANSGENIC MICE BEARING AN ELASTASE I-SV40 T-ANTIGEN FUSION GENE

被引：5

作者：

BELL, RH ^{[1
]}

BRINCKJOHNSEN, T ^{[1
]}

LONGNECKER, DS ^{[1
]}

机构：

[1] DARTMOUTH COLL,HITCHCOCK MED CTR,DARTMOUTH MED SCH,DEPT PATHOL,HINMAN 7600,HANOVER,NH 03756

来源：

PANCREAS | 1991年 / 6卷 / 04期

关键词：

STREPTOZOTOCIN; PANCREAS; INSULINOMA; SOMATOSTATIN-CELL HYPERPLASIA; FUSION GENE; ELSV; TRANSGENIC;

D O I：

10.1097/00006676-199107000-00016

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Transgenic mice, bearing a fusion gene of rat elastase I promoter and SV40 T-antigen, developed acinar cell tumors of the pancreas, as predicted by the model. In addition, they developed insulinomas and somatostatin (delta)-cell hyperplasia of the pancreatic islets. The insulinomas and the delta-cell hyperplasia appeared to be functional, as evidenced by changes in plasma glucose, insulin, and somatostatin. Streptozotocin, which has been shown to inhibit pancreatic carcinogenesis in the hamster model, significantly reduced the numbers of insulinomas and delta-cell hyperplasias. Streptozotocin did not cause a statistically significant reduction in exocrine tumors.

引用

页码：475 / 478

页数：4

共 9 条

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