INHIBITORY EFFECTS OF MAGNOSHININ AND MAGNOSALIN, COMPOUNDS FROM SHIN-I (FLOS-MAGNOLIAE), ON THE COMPETENCE AND PROGRESSION PHASES IN PROLIFERATION OF SUBCULTURED RAT AORTIC ENDOTHELIAL-CELLS

被引：14

作者：

KIMURA, I ^{[1
]}

NAGAURA, T ^{[1
]}

KOBAYASHI, S ^{[1
]}

KIMURA, M ^{[1
]}

机构：

[1] TOYAMA MED & PHARMACEUT UNIV, FAC PHARMACEUT SCI, DEPT CHEM PHARMACOL, 2630 SUGITANI, SUGITANI, TOYAMA 93001, JAPAN

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1992年 / 60卷 / 01期

关键词：

NEOLIGNAN-DERIVATIVES (MAGNOSHININ AND MAGNOSALIN); ENDOTHELIAL CELL PROLIFERATION;

D O I：

10.1254/jjp.60.59

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Anti-proliferative effects of magnoshinin and magnosalin derived from "Shin-i" (Flos magnoliae) were investigated using subcultured endothelial cells (EC) of rat aorta. The inhibitory effects of magnoshinin were 2-fold greater at 10 mug/ml than that of magnosalin on the increase in cell number when EC were stimulated by 5% fetal bovine serum. In the H-3-thymidine incorporation monitored at 3 hr-intervals, magnoshinin (0.1-3 mug/ml) prolonged the starting time of DNA synthesis and reduced the rate of incorporation into EC. Magnosalin (0.3-3 mug/ml) reduced only the incorporation rate. These results suggest that magnoshinin inhibits both the competence phase and progression phase, but magnosalin preferentially inhibits the progression phase in EC proliferation.

引用

页码：59 / 62

页数：4

共 9 条

[1] ANGIOGENESIS INVITRO [J].