DEVELOPMENTAL AUTOREGULATION OF CALCIUM CURRENTS IN MAMMALIAN CENTRAL NEURONS

被引：6

作者：

DESARMENIEN, MG

DAYANITHI, G

TAPIAARANCIBIA, L

WIDMER, H

机构：

[1] Laboratoire de Neurobiologie Endocrinologique, URA 1197 CNRS, Universite Montpellier II, Place Eugene Bataillon, Montpellier Cedex 5

来源：

NEUROREPORT | 1994年 / 5卷 / 15期

关键词：

CALCIUM; CALCIUM CURRENTS; DEVELOPMENT; FURA-2; CA2+](I); HYPOTHALAMUS; RAT;

D O I：

10.1097/00001756-199410000-00028

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE, influence of calcium currents expressed at early stages on the subsequent development of calcium currents was studied in embryonic rat hypothalamic neurones in culture. Voltage-activated calcium currents and spontaneous fluctuations of intracellular free calcium concentration ([Ca2+](i)) were monitored. Acute application of nickel chloride (0.1 mM) to 6- to 7-day-old cultures strongly reduced calcium currents and [Ca2+](i) fluctuations. When cultures were maintained for 6-7 days in the presence of NiCl2 (0.05-0.1 mM), expression the low voltage-activated current was strongly inhibited; this treatment did not affect high voltage-activated currents. Our results suggest that spontaneous activation of calcium currents early during development promotes calcium influx that regulates expression of calcium current in mature neurones.

引用

页码：1953 / 1956

页数：4

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