EXTREME INSULIN RESISTANCE IN ASSOCIATION WITH ABNORMALLY HIGH BINDING-AFFINITY OF INSULIN-RECEPTORS FROM A PATIENT WITH LEPRECHAUNISM - EVIDENCE FOR A DEFECT INTRINSIC TO THE RECEPTOR

被引:53
作者
TAYLOR, SI [1 ]
HEDO, JA [1 ]
UNDERHILL, LH [1 ]
KASUGA, M [1 ]
ELDERS, MJ [1 ]
ROTH, J [1 ]
机构
[1] UNIV ARKANSAS MED SCI, DEPT PEDIAT, LITTLE ROCK, AR 72201 USA
关键词
D O I
10.1210/jcem-55-6-1108
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:1108 / 1113
页数:6
相关论文
共 24 条
[1]   FLUCTUATIONS IN AFFINITY AND CONCENTRATION OF INSULIN RECEPTORS ON CIRCULATING MONOCYTES OF OBESE PATIENTS - EFFECTS OF STARVATION, REFEEDING, AND DIETING [J].
BAR, RS ;
GORDEN, P ;
ROTH, J ;
KAHN, CR ;
DEMEYTS, P .
JOURNAL OF CLINICAL INVESTIGATION, 1976, 58 (05) :1123-1135
[2]   REGULATION OF PLASMA-CHOLESTEROL BY LIPOPROTEIN RECEPTORS [J].
BROWN, MS ;
KOVANEN, PT ;
GOLDSTEIN, JL .
SCIENCE, 1981, 212 (4495) :628-635
[3]   CHARACTERIZATION OF ANTIBODIES TO INSULIN RECEPTOR - CAUSE OF INSULIN-RESISTANT DIABETES IN MAN [J].
FLIER, JS ;
KAHN, CR ;
JARRETT, DB ;
ROTH, J .
JOURNAL OF CLINICAL INVESTIGATION, 1976, 58 (06) :1442-1449
[4]  
HARMON JT, 1981, J BIOL CHEM, V256, P7719
[5]  
HARMON JT, 1980, J BIOL CHEM, V255, P3412
[6]  
HARMON JT, 1981, ENDOCRINOLOGY, V108, pA147
[7]   BINDING OF INSULIN-RECEPTORS TO LECTINS - EVIDENCE FOR COMMON CARBOHYDRATE DETERMINANTS ON SEVERAL MEMBRANE-RECEPTORS [J].
HEDO, JA ;
HARRISON, LC ;
ROTH, J .
BIOCHEMISTRY, 1981, 20 (12) :3385-3393
[8]   DIRECT DEMONSTRATION OF GLYCOSYLATION OF INSULIN-RECEPTOR SUBUNITS BY BIOSYNTHETIC AND EXTERNAL LABELING - EVIDENCE FOR HETEROGENEITY [J].
HEDO, JA ;
KASUGA, M ;
VANOBBERGHEN, E ;
ROTH, J ;
KAHN, CR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (08) :4791-4795
[9]   INSULIN RECEPTOR - COVALENT LABELING AND IDENTIFICATION OF SUBUNITS [J].
JACOBS, S ;
HAZUM, E ;
SHECHTER, Y ;
CUATRECASAS, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (10) :4918-4921
[10]  
JETT M, 1977, J BIOL CHEM, V252, P2134