AGE-DEPENDENT INDUCTION OF PRENEOPLASTIC LIVER-CELL FOCI BY 2-ACETYLAMINOFLUORENE, PHENOBARBITAL AND ACETAMINOPHEN IN F344 RATS INITIALLY TREATED WITH DIETHYLNITROSAMINE

被引:13
作者
HASEGAWA, R
TAKAHASHI, S
IMAIDA, K
YAMAGUCHI, S
SHIRAI, T
ITO, N
机构
[1] First Department of Pathology, Nagoya City University Medical School, Nagoya, 467, Mizuho-ku
来源
JAPANESE JOURNAL OF CANCER RESEARCH | 1991年 / 82卷 / 03期
关键词
RAT; HEPATOCARCINOGENESIS; MEDIUM-TERM BIOASSAY; GST-P-POSITIVE FOCI; AGE-DEPENDENT EFFECT;
D O I
10.1111/j.1349-7006.1991.tb01845.x
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Effects of age on the inducation of glutathione S-transferase placental form (GST-P)-positive hepatic foci in rats were examined using a medium-term liver bioassay system (for carcinogens). F344 male rats aged 6, 26 and 46 weeks were initially given a single intraperitoneal injection of diethylnitrosamine (DEN, 200 mg/kg) and, beginning 2 weeks later, received 0.02% 2-acetylaminofluorene (2-AAF), 0.05% phenobarbital (PB) or 1.3% acetaminophen (AAP) in the diet for 6 weeks. All animals were subjected to two-thirds hepatectomy 3 weeks after the DEN injection and were killed at week 8. Quantitative analysis of GST-P-positive foci revealed significantly (P < 0.001) increased induction over control levels in terms of both numbers and areas for 2-AAF at all ages (6, 26 and 46 weeks), but especially in the 6-week-old case. In the PB- and AAP-treated groups, the respective enhancing and inhibitory influences were most pronounced in the animals aged 6 weeks, and were less marked in older rats. Thus, the response of F344 rats to the modifying effects of chemicals was age-dependent, the conclusion being drawn that young rats are more susceptible and therefore more appropriate for assessment of carcinogenic, promoting and inhibitory effects of chemicals.
引用
收藏
页码:293 / 297
页数:5
相关论文
共 33 条
[1]   MODIFYING EFFECT OF AGING ON CHEMICAL CARCINOGENESIS - A REVIEW [J].
ANISIMOV, VN ;
TURUSOV, VS .
MECHANISMS OF AGEING AND DEVELOPMENT, 1981, 15 (04) :399-414
[2]   INDUCTION OF LIVER-CELL ADENOMATA IN RAT BY A SINGLE TREATMENT WITH N-METHYL-N-NITROSOUREA GIVEN AT VARIOUS TIMES AFTER PARTIAL-HEPATECTOMY [J].
CRADDOCK, VM ;
FREI, JV .
BRITISH JOURNAL OF CANCER, 1974, 30 (06) :503-511
[3]   AGING INCREASES SUSCEPTIBILITY OF MOUSE SKIN TO DMBA CARCINOGENESIS INDEPENDENT OF GENERAL IMMUNE STATUS [J].
EBBESEN, P .
SCIENCE, 1974, 183 (4121) :217-218
[4]   INDUCTION OF LIVER-CELL TUMORS IN IF MICE BY PARACETAMOL [J].
FLAKS, A ;
FLAKS, B .
CARCINOGENESIS, 1983, 4 (04) :363-368
[5]  
FUKUSHIMA S, 1987, JNCI-J NATL CANCER I, V79, P263
[6]   STUDY FOR TUMOR-INITIATING EFFECT OF ACETAMINOPHEN IN 2-STAGE LIVER CARCINOGENESIS OF MALE F344 RATS [J].
HASEGAWA, R ;
FURUKAWA, F ;
TOYODA, K ;
JANG, JJ ;
YAMASHITA, K ;
SATO, S ;
TAKAHASHI, M ;
HAYASHI, Y .
CARCINOGENESIS, 1988, 9 (05) :755-759
[7]  
HIRAGA K, 1985, JPN J CANCER RES, V76, P79
[8]   USE OF AVIDIN-BIOTIN-PEROXIDASE COMPLEX (ABC) IN IMMUNOPEROXIDASE TECHNIQUES - A COMPARISON BETWEEN ABC AND UNLABELED ANTIBODY (PAP) PROCEDURES [J].
HSU, SM ;
RAINE, L ;
FANGER, H .
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1981, 29 (04) :577-580
[9]   ENHANCING EFFECT OF VARIOUS HEPATOCARCINOGENS ON INDUCTION OF PRENEOPLASTIC GLUTATHIONE S-TRANSFERASE PLACENTAL FORM POSITIVE FOCI IN RATS - AN APPROACH FOR A NEW MEDIUM-TERM BIOASSAY SYSTEM [J].
ITO, N ;
TSUDA, H ;
TATEMATSU, M ;
INOUE, T ;
TAGAWA, Y ;
AOKI, T ;
UWAGAWA, S ;
KAGAWA, M ;
OGISO, T ;
MASUI, T ;
IMAIDA, K ;
FUKUSHIMA, S ;
ASAMOTO, M .
CARCINOGENESIS, 1988, 9 (03) :387-394
[10]  
ITO N, 1989, Toxicologic Pathology, V17, P630