SALIVARY PEPTIDE P-C MODULATES BOTH INSULIN AND GLUCAGON-RELEASE FROM ISOLATED PERFUSED RAT PANCREAS

被引：10

作者：

KIMURA, M

NAKASHIMA, N

KIMURA, I

机构：

[1] Department of Chemical Pharmacology, Faculty of Phatmaceuticai Sciences, Toyama Medical and Pharmaceutical University

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1990年 / 52卷 / 04期

关键词：

D O I：

10.1254/jjp.52.579

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of salivary peptide P-C, saliva-derived peptide on glucose-induced insulin release was studied using perfused rat pancreas. Salivary peptide P-C (194 nM) remarkably potentiated glucose (8.3 and 16.7 mM)-induced insulin release, whereas the same concentration suppressed arginine (10 mM)-induced glucagon release. Both effects of salivary peptide P-C occurred in a concentration-dependent manner. These findings suggest that salivary peptide P-C may modulate both the levels of insulin and glucagon in vivo. © 1990, The Japanese Pharmacological Society. All rights reserved.

引用

页码：579 / 585

页数：7

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