DIFFERENTIAL REGULATION OF MANGANESE AND COPPER-ZINC SUPEROXIDE DISMUTASES BY THE FACIAL-NERVE TRANSECTION

被引：25

作者：

YONEDA, T ^{[1
]}

INAGAKI, S ^{[1
]}

HAYASHI, Y ^{[1
]}

NOMURA, T ^{[1
]}

TAKAGI, H ^{[1
]}

机构：

[1] OSAKA CITY UNIV, SCH MED, DEPT ANAT 1, ASAHIMACHI 1-4-54, ABENO KU, OSAKA 545, JAPAN

来源：

BRAIN RESEARCH | 1992年 / 582卷 / 02期

关键词：

SUPEROXIDE DISMUTASE; MOTONEURON; AXOTOMY; FACIAL NERVE; INSITU HYBRIDIZATION;

D O I：

10.1016/0006-8993(92)90153-Z

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of unilateral nerve transection on manganese and copper/zinc superoxide dismutase (Mn-SOD and Cu/Zn-SOD) mRNA levels in the facial nucleus were studied by in situ hybridization. An increase of Mn-SOD mRNA levels was first seen in the ipsilateral facial nucleus 12 h after axotomy, and was most pronounced at 4-7 days after this procedure; by 56 days, the increase disappeared. There was no change in Cu/Zn-SOD mRNA levels at any time after axotomy. We further confirmed, by immunohistochemistry, that the increase in Mn-SOD transcription was followed by protein synthesis. These results are suggestive of an important role for Mn-SOD in defense, regeneration and recovery responses following nerve transection.

引用

页码：342 / 345

页数：4

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