HOMOTYPIC AND HETEROTYPIC CA++-INDEPENDENT CELL-ADHESION ACTIVITIES OF BILIARY GLYCOPROTEIN, A MEMBER OF CARCINOEMBRYONIC ANTIGEN FAMILY, EXPRESSED ON CHO CELL-SURFACE

被引：103

作者：

OIKAWA, S

KUROKI, M

MATSUOKA, Y

KOSAKI, G

NAKAZATO, H

机构：

[1] TOKYO METROPOLITAN KOMAGOME HOSP,BUNKYO KU,TOKYO 113,JAPAN

[2] FUKUOKA UNIV,SCH MED,DEPT BIOCHEM 1,JONAN KU,FUKUOKA 81401,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 186卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)90828-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Homotypic and heterotypic cell adhesion activities of a carcinoembryonic antigen (CEA) family member, biliary glycoprotein a (BGPa), have been examined. CHO cells transfected with the cDNA for BGPa, CEA, non-specific cross-reacting antigen (NCA) and CGM6 have been used. The BGPa producers showed both homotypic and heterotypic adhesion to CEA and NCA producers. However, they hardly adhered to CGM6 producers. Calcium ion was not required for BGPa-mediated homotypic and heterotypic cell adhesion as well as for the adhesions of other members of CEA family. The results strongly suggested that BGPa may play some important roles through Ca++-independent cell adhesion activities. © 1992.

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页码：881 / 887

页数：7

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