RADICAL-BASED SYNTHESES OF 5-BENZOYL-1,2-DIHYDRO-3H-PYRROLO[1,2-A]PYRROLE-1-CARBOXYLIC ACID (KETOROLAC)

被引：51

作者：

ARTIS, DR ^{[1
]}

CHO, IS ^{[1
]}

MUCHOWSKI, JM ^{[1
]}

机构：

[1] SYNTEX INC,INST ORGAN CHEM,3401 HILLVIEW AVE,PALO ALTO,CA 94304

来源：

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE | 1992年 / 70卷 / 06期

关键词：

D O I：

10.1139/v92-228

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Short, efficient, and convergent syntheses of ketorolac (1) based on the inter- or intramolecular oxidative addition of malonyl and substituted malonyl radicals to 2-benzoylpyrrole and derivatives thereof are described.

引用

页码：1838 / 1842

页数：5

共 16 条

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[5] CARBOLACTONIZATION OF OLEFINS UNDER MILD CONDITIONS BY CYANOACETIC AND MALONIC-ACIDS PROMOTED BY MANGANESE(III) ACETATE
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[6] NOVEL SYNTHESES OF 5-AROYL-1,2-DIHYDRO-3H-PYRROLO[1,2-A]PYRROLE-1-CARBOXYLIC ACIDS
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[7] GIESE B, 1986, RADICALS ORGANIC SYN, P86
[8] PROTECTING GROUPS FOR THE PYRROLE NITROGEN ATOM - THE 2-CHLOROETHYL, 2-PHENYLSULFONYLETHYL, AND RELATED MOIETIES
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[10] Muchowski J. M., 1992, ADV MED CHEM, V1, P109, DOI DOI 10.1096/FJ.01-0024LSF

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